In 1857, he married Sophia Karlovna Hertz, sister of the art historian Karl Hertz (1820-1883). In their home they entertained artistic people and collectors including Pavel Tretyakov. Savrasov became especially close with Vasily Perov. Perov helped him paint the figures of the boat trackers in Savrasov's Volga near Yuryevets, Savrasov painted landscapes for Perov's Bird catcher and Hunters on Bivouac.

In the 1860s, he traveled to England to see the International Exhibition, and to Switzerland. In one of his letters he wrote that no academies in the world could so advance an artist as the present world exhibition. The painters who influenced him most were British painter John Constable and Swiss painter Alexandre Calame.

The Rooks Have Come Back (1871) is considered by many critics to be the high point in Savrasov’s artistic career. Using a common, even trivial, episode of birds returning home, and an extremely simple landscape, Savrasov emotionally showed the transition of nature from winter to spring. It was a new type of lyrical landscape painting, called later by critics the mood landscape. The painting brought him fame. In 1870, he became a member of the Peredvizhniki group, breaking with government-sponsored academic art.

In the late 1870s, he gradually became an alcoholic. The process may have begun with the death of his daughter in 1871, which led to a crisis in his art and, possibly, dissatisfaction with his artistic career. In 1882, he was dismissed from his position at the MSPSA. All attempts of his relatives and friends to help him were in vain.

His work suffered dramatically and the last years of his life were spent in poverty. He was usually drunk and often dressed in rags. Finally, he found himself wandering from shelter to shelter. Only the doorkeeper of the MSPSA and Pavel Tretyakov, founder of the Tretyakov Gallery, were present at his funeral in 1897.